L1- Arterial Blood Gas Interpretation

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Arterial Blood Gas Interpretation Normal Arterial Blood Gas Values* The Key to Blood Gas Interpretation: 4 Equations, 3 Physiologic Processes 1) PaCO2 equation: PaCO2 reflects ratio of metabolic CO2 production to alveolar ventilation Hypercapnia Hypercapnia (elevated PaCO2) is a serious respiratory problem.  The PaCO2 equation shows that the only physiologic reason for elevated PaCO2 is inadequate alveolar ventilation (VA) for the amount of the body’s CO2 production (VCO2).  Since alveolar ventilation (VA) equals total or minute ventilation (VE) minus dead space ventilation (VD), hypercapnia can arise from insufficient VE, increased VD, or a combination. Examples of inadequate VE leading to decreased VA and increased PaCO2:  sedative drug overdose; respiratory muscle paralysis; central hypoventilation Examples of increased VD leading to decreased VA and increased PaCO2:  chronic obstructive pulmonary disease; severe restrictive lung disease (with shallow, rapid breathing) Clinical assessment of hypercapnia is unreliable -The PaCO2 equation shows why PaCO2 cannot reliably be assessed clinically.  Since you never know the patient's VCO2 or VA, you cannot determine the VCO2/VA, which is what PaCO2 provides.  (Even if tidal volume is measured, you can’t determine the amount of air going to dead space.) -There is no predictable correlation between PaCO2 and the clinical picture.  In a patient with possible respiratory disease, respiratory rate, depth, and effort cannot be reliably used to predict even a directional change in PaCO2.  A patient in respiratory distress can have a high, normal, or low PaCO2.  A patient without respiratory distress can have a high, normal, or low PaCO2. Dangers of hypercapnia -Besides indicating a serious derangement in the respiratory system, elevated PaCO2 poses a threat for three reasons: 1)  An elevated PaCO2 will lower the PAO2 (see Alveolar gas equation), and as a result lower the PaO2. 2)  An elevated PaCO2
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